The Involvement of S100A14 in Cell Invasion by Affecting Expression and Function of Matrix Metalloproteinase (MMP)-2 via P53-dependent Transcriptional Regulation
نویسندگان
چکیده
Background: The role of S100A14 in tumorigenesis and the underlying mechanisms have not been fully understood. Results: S100A14 affects cell invasiveness by regulating MMP2 transcription in a p53-dependent manner. Conclusion: S100A14 acts as either an inducer or an inhibitor of cell invasion depending on the p53 status of cells. Significance: These studies significantly increase our understanding of how S100A14 regulates cell invasiveness.
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